Journal article
Takahiro Inoue, M. Okamura, Mika Kitahara, Y. Takamatsu, H. Sakakima, H. Maejima
Neuroscience, 2020
Neuroscience, 2020
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APA
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Inoue, T., Okamura, M., Kitahara, M., Takamatsu, Y., Sakakima, H., & Maejima, H. (2020). Exercise plus pharmacological neuromodulation of synaptic inhibition enhance motor function recovery after ischemic stroke. Neuroscience.
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Inoue, Takahiro, M. Okamura, Mika Kitahara, Y. Takamatsu, H. Sakakima, and H. Maejima. “Exercise plus Pharmacological Neuromodulation of Synaptic Inhibition Enhance Motor Function Recovery after Ischemic Stroke.” Neuroscience (2020).
MLA
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Inoue, Takahiro, et al. “Exercise plus Pharmacological Neuromodulation of Synaptic Inhibition Enhance Motor Function Recovery after Ischemic Stroke.” Neuroscience, 2020.
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@article{takahiro2020a,
title = {Exercise plus pharmacological neuromodulation of synaptic inhibition enhance motor function recovery after ischemic stroke.},
year = {2020},
journal = {Neuroscience},
author = {Inoue, Takahiro and Okamura, M. and Kitahara, Mika and Takamatsu, Y. and Sakakima, H. and Maejima, H.}
}
Abstract
OBJECTIVES The objective of this study was to examine the interactive effects of exercise and low-level inhibition of GABAA receptors on the recovery of motor function and BDNF expression in the primary motor cortex (M1) of a stroke rat model.
METHODS Male Sprague-Dawley rats were divided into 5 groups: sham (SHAM), control (CON), exercise (EX), bicuculline (BIC), and bicuculline plus exercise (BICEX) groups. All rats, except those in the SHAM group, underwent middle cerebral artery occlusion (MCAO) surgery to induce an ischemic stroke. GABAA receptor antagonist, bicuculline (0.25 mg/kg, i.p.), was administered to the BIC and BICEX groups. The EX and BICEX groups exercised on a treadmill (11 m/min for 30 min). Each intervention started 3 days after the MCAO surgery and was carried out every day for 2 weeks. Following the intervention, bilateral M1 BDNF mRNA and protein expression levels were assessed using qRT-PCR and ELISA.
RESULTS Marginal recovery was found in the EX and BIC groups, whereas motor function recovery was enhanced with exercise in the presence of bicuculline administration specifically in the BICEX group. Furthermore, BDNF protein level in the ipsilateral M1 was significantly higher in the BICEX group than in other groups.
CONCLUSIONS This study indicated that exercise combined with low-level inhibition of GABAA receptors after stroke could facilitate the recovery of motor function accompanied by BDNF upregulation in the ipsilateral M1. Therefore, this study provides a novel insight of pharmacological neuromodulation into stroke rehabilitation.