Specific inhibition of α5 subunit-containing GABAA receptors enhances locomotor activity and neuronal activity in the motor cortex.

Journal article

Takahiro Inoue, Y. Takamatsu, M. Okamura, Hiroki Mani, Naoya Hasegawa, H. Maejima
Biomedical research, 2021

Cite

APA Click to copy
Inoue, T., Takamatsu, Y., Okamura, M., Mani, H., Hasegawa, N., & Maejima, H. (2021). Specific inhibition of α5 subunit-containing GABAA receptors enhances locomotor activity and neuronal activity in the motor cortex. Biomedical Research.

Chicago/Turabian Click to copy
Inoue, Takahiro, Y. Takamatsu, M. Okamura, Hiroki Mani, Naoya Hasegawa, and H. Maejima. “Specific Inhibition of α5 Subunit-Containing GABAA Receptors Enhances Locomotor Activity and Neuronal Activity in the Motor Cortex.” Biomedical research (2021).

MLA Click to copy
Inoue, Takahiro, et al. “Specific Inhibition of α5 Subunit-Containing GABAA Receptors Enhances Locomotor Activity and Neuronal Activity in the Motor Cortex.” Biomedical Research, 2021.

BibTeX Click to copy

@article{takahiro2021a,
  title = {Specific inhibition of α5 subunit-containing GABAA receptors enhances locomotor activity and neuronal activity in the motor cortex.},
  year = {2021},
  journal = {Biomedical research},
  author = {Inoue, Takahiro and Takamatsu, Y. and Okamura, M. and Mani, Hiroki and Hasegawa, Naoya and Maejima, H.}
}

Abstract

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system (CNS). This study examined the effect of specific inhibition of α5 subunit-containing GABAA receptors (α5GABAAR) on the behavioral profile and neuronal activity of the CNS using a compound called L-655,708, which is a selective negative allosteric modulator of α5GABAAR. L-655,708 administration significantly increased locomotor activity without anxiety-related behavior. Furthermore, L-655,708 administration significantly increased c-Fos mRNA expression (a neuronal activity marker) in motor area of the cerebral cortex, whereas it hardly altered c-Fos mRNA expression in the sensory cortex, hippocampus, and spinal cord. This study revealed for the first time that alteration of neuronal activity with specific inhibition of α5GABAAR differs depending on each CNS region. α5GABAAR could be a potential target for modulating CNS excitability and behavioral activity.